GENE-SWitCH is a 4-year project structured in 3 pillars and organised in 7 WPs: WP1, 2 and 3 (Pillar 1: light blue), WP4 and 5 (Pillar 2: green), WP3 and 6 (Pillar 3: dark blue), plus project coordination (WP7).
The research activities of GENE-SWitCH are grouped in Pillar 1 and Pillar 2. Pillar 1 (WP1, WP2, and WP3) represents the ‘core’ FAANG annotation of GENE-SWitCH while Pillar 2 (WP4 and WP5) implements FAANG innovation (new genomic prediction models and a diet x epigenetics study in pigs).
WP1 - Sample collection and assays-bysequence (DIAGEN)
The aim is to carry out sample collections of the selected panel of tissues from pig and chicken and to annotate the functional elements of these genomes by standardized FAANG molecular assays. Read more.
WP2 - New annotation maps of pig and chicken genomes (UEDIN)
The aim is to to annotate the functional elements of pig and chicken (reflecting transcript diversity and expression levels, areas of open chromatin, methylation status, histone marks reflecting active or repressive regions of the genome, spatial organisation of the genome and putative regulatory regions, i.e. enhancer, promoters, repressors, insulators). Read more.
WP3 - FAANG Data Coordination, Standardisation and Integration (EMBL)
The aim is to support data coordination, curation, validation, archiving, dissemination and publication through the European biological data archives and FAANG data portal. Read more.
WP4 - Improving predictive models for genomic selection (HG)
The aim is to develop and validate genomic prediction models that use functional information (generated for major tissues in WP1 and WP2), on top of the commonly used phenotypic and genotypic data. Read more.
WP5 - Influence of maternal diet on epigenetic programming of offspring (WU)
The aim is to explore the epigenetic and transcriptional effects triggered by maternal diets differing in fibre contents on pig fetal tissues, and the possible persistence of such effects until the post-weaning stage. Read more.
WP6 - Outreach, dissemination and training (EFFAB)
The aim is to ensure broad dissemination and communication and to facilitate uptake of the GENE-SWitCH outcomes. Read more.
WP7 - Project management and consortium coordination (INRAE)
The aim is to create a project environment that maximizes interaction between partners and disciplines. Read more.
WP8 - Ethics (INRAE)
This work package sets out the ethics requirements that the project must comply with.
WP1 - Sample collection and assays-by-sequence
WP2 - New annotation maps of pig and chicken genomes
WP3 - FAANG Data Coordination, Standardisation and Integration
WP4 - Improving predictive models for genomic selection
WP5 - Influence of maternal diet on epigenetic programming of offspring
WP6 - Outreach, dissemination and training
WP7 - Project management and consortium coordination
WP8 - Ethics
The GENE-SWitCH project has received funding from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No 817998. This publication reflects the views only of the author, and the European Union cannot be held responsible for any use which may be made of the information contained therein.